Precise manipulation of neural activity is essential for developing advanced neuroprosthetic systems. Achieving this requires a careful balance between resolution and invasiveness. Using tissue-integrated ultraflexible electrodes, we are developing high-resolution, chronically stable microstimulation techniques that selectively and repeatedly modulate small groups of neurons with complex spatiotemporal patterns mimicking natural neural coding. This technology can potentially revolutionize neuroprosthetic precision, enabling more effective and targeted restoration of function.

Neuroplasticity, the brain's capacity to reorganize and adapt following injury, provides a critical opportunity to understand how neural circuits compensate for damage. By examining the mechanisms driving post-stroke recovery, we seek to uncover strategies to amplify adaptive plasticity, mitigate maladaptive changes, and develop precise neuromodulation interventions that facilitate recovery and restore function. Our unique approach integrates simultaneous monitoring of neural, vascular, and inflammatory responses with open- and closed-loop neuromodulation, enabling targeted manipulation of neural activity to optimize outcomes.

The development of high-density, ultraflexible electrodes (NETs) has enabled us to record and track a large number of neurons, not only in multiple brain regions but also in the highly mobile spinal cord, a challenging part of the CNS to readout neural activity.  This unique capability allows us to capture rapid millisecond-level responses critical for movement coordination and sensory processing, as well as decipher slower changes associated with learning and adaptation. Our research focuses on sensory and motor systems, aiming to leverage these insights to advance neuroprosthetic technologies and to develop novel treatment strategies for disorders.

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